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Protein Modification Reagents

Chemical agents used to modify the amino acid side chains of proteins in order to alter their native charges, block or expose reactive binding sites, inactivate functional groups, and change functional groups to create targets for crosslinking and labeling.
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2,311 – 2,325 of 5,667 results
2,311

Chemscene ChemScene | Mal-PEG6-NHS ester | 250MG | CS-0104984 | 0.98 | 1599472-25-9| MFCD20926374 | 530.52
SDP

ChemScene | Mal-PEG6-NHS ester | 250MG | CS-0104984 | 0.98 | 1599472-25-9| MFCD20926374 | 530.52

ENCOMPASS_PREFERRED
2,312

Broadpharm FLUORESCEIN-DBCO

NC3654433 FLUORESCEIN-DBCO

ENCOMPASS
2,313

Medchemexpress LLC Sulfo DBCO-amine | 2028284-70-8 | MFCD30458046 | 99.0% | 427.47 g/mol | C21H21N3O5S | 5 MG
SDP

Sulfo DBCO-amine is a water-soluble click-chemistry reagent containing a dibenzocyclooctyne (DBCO) moiety that enables strain-promoted alkyne-azide cycloaddition (SPAAC) for efficient, copper-free bioconjugation. It is commonly used as a linker or building block in PROTAC synthesis and other bioconjugation workflows, and is supplied in small quantities for research use.

  • Enables copper-free SPAAC bioconjugation.
  • Water-soluble sulfonate improves aqueous compatibility.
  • Contains a reactive amine for stable amide coupling.
  • High purity suitable for research-grade applications.
  • Available in small quantities for exploratory synthesis.

ENCOMPASS_PREFERRED
2,314

Vector Laboratories VECTOR LABORATORIES LLC

NC3939003 AMINO-DPEG-ACID 2

ENCOMPASS
2,315

Medchemexpress LLC Mal-PEG2-NHS | 25MG
SDP

Mal-PEG2-NHS | 25MG

ENCOMPASS_PREFERRED
2,316

eMolecules​ 289714-02-9 | Biotin-PEG3-alcohol | Broadpharm | MFCD26142988 | 375.480 | C16H29N3O5S | 0.000 | OCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 500mg | 353441919

Biotin-PEG3-alcohol | Broadpharm | 289714-02-9 | MFCD26142988 | 375.480 | C16H29N3O5S | 0.000 | OCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 | 500mg | 353441919

ENCOMPASS_PREFERRED
2,317

Vector Laboratories VECTOR LABORATORIES LLC

NC3939008 AMINO-DPEG-T-BUTYL ESTER 1

ENCOMPASS
2,318

Broadpharm Methyltetrazine-PEG12-DBCO| 25MG

Methyltetrazine-PEG12-DBCO| 25MG

ENCOMPASS
2,319

Medchemexpress LLC HS-PEG3-CH2CH2NH2 hydrochloride | 2863676-86-0 | 95.0% | 100 MG
SDP

HS-PEG3-CH2CH2NH2 hydrochloride is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs function by leveraging the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

  • PEG-based PROTAC linker
  • Used in the synthesis of PROTACs
  • PROTACs utilize two distinct ligands connected by a linker
  • Selectively degrades target proteins through the ubiquitin-proteasome system

ENCOMPASS_PREFERRED
2,320

Medchemexpress LLC Nh2-peg4-dota | 2090232-34-9 | 97.0% | 622.71 g/mol | C26H50N6O11 | 50mg
SDP

NH2-PEG4-DOTA is a bifunctional DOTA-type metal chelator NH2-PEG4-DOTA can be conjugated with Dextran for quantitative analysis in the presence of a highly luminescent complex NH2-PEG4-DOTA can also bind to radionuclides to prepare radionuclide drug conjugates (RDCs) RDCs have the ability to specifically target biomolecules and can be used in medical imaging or therapy

ENCOMPASS_PREFERRED
2,321

Broadpharm Methyltetrazine-PEG4-maleimide| 10MG| MOLWT: 514.5

Methyltetrazine-PEG4-maleimide| 10MG| MOLWT: 514.5

ENCOMPASS
2,322

Medchemexpress LLC 2-(2-azidoethoxy)ethyl 4-methylbenzenesulfonate | 182347-24-6 | MFCD27946436 | 99.8% | 285.32 g/mol | C11H15N3O4S | 500 MG
SDP

N3-PEG2-Tos is an azide-terminated PEG2 tosylate linker used as a synthetic building block for organic synthesis and bioconjugation. The tosylate is a good leaving group for nucleophilic substitution, and the azide serves as a click-chemistry handle for rapid, selective conjugation under copper-catalyzed conditions.

  • Azide functional group for copper-catalyzed azide-alkyne cycloaddition.
  • Tosylate leaving group enables efficient nucleophilic substitution.
  • Short PEG2 spacer provides flexibility and improved solubility in common organic solvents.
  • High reported purity supports consistent reaction performance.
  • Available in multiple package sizes to suit different synthesis scales.

ENCOMPASS_PREFERRED
2,323

eMolecules​ 2183473-14-3 | BDP FL-PEG4-amine TFA salt | Broadpharm510.390 | C24H37BF2N4O5 | 98.000 | CC1=CC(C)=[N+]2C1=Cc1ccc(CCC(=O)NCCOCCOCCOCCOCCN)n1[B-]2(F)F | 100mg | 462125625

BDP FL-PEG4-amine TFA salt | Broadpharm | 2183473-14-3510.390 | C24H37BF2N4O5 | 98.000 | CC1=CC(C)=[N+]2C1=Cc1ccc(CCC(=O)NCCOCCOCCOCCOCCN)n1[B-]2(F)F | 100mg | 462125625

ENCOMPASS_PREFERRED
2,324

eMolecules​ 2028288-77-7 | TCO-C3-PEG3-C3-amine | Broadpharm | MFCD30458038 | 372.506 | C19H36N2O5 | 0.000 | NCCCOCCOCCOCCCNC(=O)OC1CCC\C=C\CC1 | 500mg | 340377121

TCO-C3-PEG3-C3-amine | Broadpharm | 2028288-77-7 | MFCD30458038 | 372.506 | C19H36N2O5 | 0.000 | NCCCOCCOCCOCCCNC(=O)OC1CCC\C=C\CC1 | 500mg | 340377121

ENCOMPASS_PREFERRED
2,325

eMolecules​ 2093152-86-2 | N-(Amino-PEG5)-N-bis(PEG4-acid), HCl salt | Broadpharm | MFCD30723284 | 776.915 | C34H68N2O17 | 95.000 | NCCOCCOCCOCCOCCOCCN(CCOCCOCCOCCOCCC(O)=O)CCOCCOCCOCCOCCC(O)=O | 500mg | 340376983

N-(Amino-PEG5)-N-bis(PEG4-acid), HCl salt | Broadpharm | 2093152-86-2 | MFCD30723284 | 776.915 | C34H68N2O17 | 95.000 | NCCOCCOCCOCCOCCOCCN(CCOCCOCCOCCOCCC(O)=O)CCOCCOCCOCCOCCC(O)=O | 500mg | 340376983

ENCOMPASS_PREFERRED